| 1. Round | 13/08/2000 | Sint-Truidense VV | - | RSC Anderlecht | 0:0 |  |
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| 3. Round | 26/08/2000 | RSC Anderlecht | - | KSK Beveren | 4:0 | ||||
| 13. Round | 18/11/2000 | RSC Anderlecht | - | RAA La Louviére | 2:0 | ||||
| 15. Round | 01/12/2000 | RSC Anderlecht | - | Club Brugge KV | 2:0 | ||||
| 18. Round | 20/12/2000 | RSC Anderlecht | - | Sint-Truidense VV | 3:2 | ||||
| 20. Round | 27/01/2001 | KSK Beveren | - | RSC Anderlecht | 1:3 | ||||
| 21. Round | 02/02/2001 | RSC Charleroi | - | RSC Anderlecht | 0:4 |  |
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| 22. Round | 09/02/2001 | RSC Anderlecht | - | Royal Antwerp FC | 2:0 | ||||
| 23. Round | 18/02/2001 | KRC Harelbeke | - | RSC Anderlecht | 1:4 | ||||
| 19. Round | 24/02/2001 | KVC Westerlo | - | RSC Anderlecht | 2:2 | ||||
| 24. Round | 03/03/2001 | Lierse SK (old) | - | RSC Anderlecht | 0:0 | ||||
| 30. Round | 20/04/2001 | RAA La Louviére | - | RSC Anderlecht | 0:1 | ||||
| 31. Round | 28/04/2001 | RSC Anderlecht | - | Germinal Beerschot | 7:0 | ||||
| 32. Round | 05/05/2001 | Club Brugge KV | - | RSC Anderlecht | 0:1 | ||||
| 33. Round | 12/05/2001 | RSC Anderlecht | - | KV Mechelen | 1:0 | ||||
| 34. Round | 20/05/2001 | K.S.C. Eendracht Aalst | - | RSC Anderlecht | 1:5 |
Kosovo
