| 1. Round | 01/08/2021 | CD Walter Ferretti | - | Real Madriz | 4:1 | ||||
| 2. Round | 08/08/2021 | CD Walter Ferretti | - | Club Deportivo Ocotal | 4:0 | ||||
| 4. Round | 22/08/2021 | ART Municipal Jalapa | - | CD Walter Ferretti | 2:0 | ||||
| 8. Round | 07/10/2021 | Real Estelí FC | - | CD Walter Ferretti | 1:1 | ||||
| 11. Round | 10/10/2021 | Club Deportivo Ocotal | - | CD Walter Ferretti | 3:0 | ||||
| 12. Round | 17/10/2021 | Diriangén FC | - | CD Walter Ferretti | 4:2 | ||||
| 14. Round | 25/10/2021 | UNAN Managua | - | CD Walter Ferretti | 0:1 | ||||
| 15. Round | 31/10/2021 | CD Walter Ferretti | - | H&H Export Sébaco | 2:1 | ||||
| 16. Round | 03/11/2021 | Juventus Managua | - | CD Walter Ferretti | 2:2 | ||||
| 17. Round | 19/11/2021 | CD Walter Ferretti | - | Real Estelí FC | 4:0 |  |
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| 18. Round | 22/11/2021 | Managua FC | - | CD Walter Ferretti | 3:1 |
Nicaragua