| 1. Round | 06/08/2005 | KVC Westerlo | - | Cercle Brugge | 2:0 | ||||
| 2. Round | 13/08/2005 | Germinal Beerschot | - | KVC Westerlo | 0:1 |  |
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| 3. Round | 20/08/2005 | KVC Westerlo | - | KRC Genk | 1:1 | ||||
| 4. Round | 27/08/2005 | Excelsior Mouscron | - | KVC Westerlo | 1:0 | ||||
| 5. Round | 10/09/2005 | KVC Westerlo | - | FC Brussels | 3:0 | ||||
| 7. Round | 21/09/2005 | KVC Westerlo | - | Lierse SK (old) | 0:0 | ||||
| 8. Round | 24/09/2005 | Sint-Truidense VV | - | KVC Westerlo | 0:1 | ||||
| 11. Round | 22/10/2005 | KVC Westerlo | - | Sporting Lokeren | 1:1 | ||||
| 12. Round | 29/10/2005 | Sporting Charleroi | - | KVC Westerlo | 2:1 | ||||
| 13. Round | 06/11/2005 | Standard Liège | - | KVC Westerlo | 1:0 | ||||
| 14. Round | 20/11/2005 | KVC Westerlo | - | RSC Anderlecht | 2:1 | ||||
| 16. Round | 03/12/2005 | KVC Westerlo | - | SV Zulte Waregem | 2:2 | ||||
| 17. Round | 10/12/2005 | RAA La Louviére | - | KVC Westerlo | 0:3 | |
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| 15. Round | 14/12/2005 | KAA Gent | - | KVC Westerlo | 0:1 | |
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| 18. Round | 17/12/2005 | Cercle Brugge | - | KVC Westerlo | 2:2 | |
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| 19. Round | 21/01/2006 | KVC Westerlo | - | Germinal Beerschot | 1:3 | ||||
| 20. Round | 28/01/2006 | KRC Genk | - | KVC Westerlo | 2:0 |
Belgium