| 1. Round | 13/03/2022 | Sepsi OSK | - | CS Mioveni | 3:1 |  |
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| 2. Round | 20/03/2022 | Dinamo Bucureşti | - | Sepsi OSK | 0:0 | ||||
| 3. Round | 04/04/2022 | Sepsi OSK | - | Academica Clinceni | 6:0 |  |
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| 4. Round | 10/04/2022 | FC Botoşani | - | Sepsi OSK | 0:1 | ||||
| 5. Round | 16/04/2022 | Sepsi OSK | - | UTA Arad | 1:0 | ||||
| 6. Round | 23/04/2022 | Rapid Bucureşti | - | Sepsi OSK | 1:0 | |
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| 7. Round | 29/04/2022 | Sepsi OSK | - | Gaz Metan Mediaş | 3:1 | |
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| 8. Round | 08/05/2022 | Sepsi OSK | - | Chindia Târgoviște | 2:1 | ||||
| 9. Round | 16/05/2022 | FC Universitatea Craiova | - | Sepsi OSK | 0:5 |
Romania