| 1. Round | 16/07/2022 | Jagiellonia Białystok | - | Piast Gliwice | 2:0 |  |
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| 2. Round | 22/07/2022 | Jagiellonia Białystok | - | Widzew Łódź | 0:2 | ||||
| 3. Round | 31/07/2022 | Pogoń Szczecin | - | Jagiellonia Białystok | 1:0 | ||||
| 4. Round | 06/08/2022 | Jagiellonia Białystok | - | Radomiak Radom | 1:2 | |
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| 5. Round | 14/08/2022 | Raków Częstochowa | - | Jagiellonia Białystok | 2:2 | |
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| 6. Round | 19/08/2022 | Jagiellonia Białystok | - | Miedź Legnica | 2:1 | ||||
| 7. Round | 26/08/2022 | Górnik Zabrze | - | Jagiellonia Białystok | 1:1 | |
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| 9. Round | 12/09/2022 | Jagiellonia Białystok | - | FKS Stal Mielec | 4:0 | ||||
| 10. Round | 17/09/2022 | Lechia Gdańsk | - | Jagiellonia Białystok | 2:2 | |
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| 11. Round | 02/10/2022 | Jagiellonia Białystok | - | Korona Kielce | 4:1 | ||||
| 12. Round | 07/10/2022 | Jagiellonia Białystok | - | Wisła Płock | 1:1 | |
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| 13. Round | 15/10/2022 | Warta Poznań | - | Jagiellonia Białystok | 2:0 | |
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| 14. Round | 23/10/2022 | Śląsk Wrocław | - | Jagiellonia Białystok | 2:2 | |
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| 16. Round | 05/11/2022 | KS Cracovia | - | Jagiellonia Białystok | 1:0 | ||||
| 17. Round | 12/11/2022 | Jagiellonia Białystok | - | Lech Poznań | 1:2 |
Romania