1. Round | 18/07/2021 | Spartak Subotica | - | Radnički Niš | 1:1 | ||||
2. Round | 24/07/2021 | Radnički Niš | - | FK Napredak | 4:2 | ||||
3. Round | 31/07/2021 | Radnik Surdulica | - | Radnički Niš | 1:1 | ||||
4. Round | 09/08/2021 | Radnički Niš | - | TSC Bačka Topola | 1:2 | ||||
5. Round | 15/08/2021 | FK Čukarički | - | Radnički Niš | 0:0 | ||||
6. Round | 23/08/2021 | Radnički Niš | - | Proleter Novi Sad | 0:1 | ||||
7. Round | 29/08/2021 | Partizan | - | Radnički Niš | 4:0 | ||||
8. Round | 12/09/2021 | Radnički Niš | - | FK Voždovac | 1:0 | ||||
12. Round | 03/10/2021 | Vojvodina | - | Radnički Niš | 1:1 | ||||
14. Round | 24/10/2021 | Crvena Zvezda | - | Radnički Niš | 1:0 | ||||
15. Round | 30/10/2021 | Radnički Niš | - | Mladost Lučani | 2:0 | ||||
13. Round | 03/11/2021 | Radnički Niš | - | FK Radnički 1923 | 2:1 | ||||
16. Round | 07/11/2021 | Radnički Niš | - | Spartak Subotica | 0:0 | ||||
19. Round | 06/12/2021 | TSC Bačka Topola | - | Radnički Niš | 1:1 | ||||
21. Round | 16/12/2021 | Proleter Novi Sad | - | Radnički Niš | 0:3 dec. |