| 1. Round | 21/08/2021 | Cape Town City FC | - | SuperSport United | 0:0 | ||||
| 2. Round | 25/08/2021 | SuperSport United | - | Golden Arrows | 3:1 | ||||
| 3. Round | 14/09/2021 | AmaZulu FC | - | SuperSport United | 0:0 | ||||
| 9. Round | 02/11/2021 | Royal AM | - | SuperSport United | 2:1 | ||||
| 10. Round | 05/11/2021 | SuperSport United | - | TS Galaxy | 2:1 | ||||
| 11. Round | 20/11/2021 | SuperSport United | - | Marumo Gallants | 1:2 | ||||
| 19. Round | 24/11/2021 | Mamelodi Sundowns | - | SuperSport United | 2:2 | ||||
| 13. Round | 05/12/2021 | SuperSport United | - | Sekhukhune United | 0:1 | ||||
| 14. Round | 08/12/2021 | Stellenbosch FC | - | SuperSport United | 0:1 |  |
South Africa