1. Round | 31/07/2021 | Diriangén FC | - | UNAN Managua | 2:1 | ||||
2. Round | 10/08/2021 | UNAN Managua | - | H&H Export Sébaco | 0:2 | ||||
3. Round | 15/08/2021 | UNAN Managua | - | ART Municipal Jalapa | 1:0 | ||||
4. Round | 23/08/2021 | UNAN Managua | - | Real Madriz | 3:5 | ||||
5. Round | 30/08/2021 | CD Walter Ferretti | - | UNAN Managua | 1:1 | ||||
6. Round | 02/09/2021 | Real Estelí FC | - | UNAN Managua | 4:1 | ||||
8. Round | 20/09/2021 | Club Deportivo Ocotal | - | UNAN Managua | 1:2 | ||||
10. Round | 02/10/2021 | UNAN Managua | - | Diriangén FC | 0:5 | ||||
11. Round | 10/10/2021 | H&H Export Sébaco | - | UNAN Managua | 1:1 | ||||
14. Round | 25/10/2021 | UNAN Managua | - | CD Walter Ferretti | 0:1 | ||||
17. Round | 18/11/2021 | UNAN Managua | - | Club Deportivo Ocotal | 2:3 |