| 1. Round | 02/08/2020 | Diriangén FC | - | Chinandega | 2:0 | ||||
| 2. Round | 09/08/2020 | Chinandega | - | Real Estelí FC | 1:5 | ||||
| 3. Round | 13/08/2020 | Managua FC | - | Chinandega | 1:0 |  |
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| 4. Round | 16/08/2020 | Chinandega | - | Club Deportivo Ocotal | 4:2 | |
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| 5. Round | 23/08/2020 | Chinandega | - | Junior Managua | 2:2 | ||||
| 6. Round | 31/08/2020 | Real Madriz | - | Chinandega | 0:1 | |
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| 7. Round | 06/09/2020 | Chinandega | - | Juventus Managua | 3:2 | ||||
| 8. Round | 14/09/2020 | ART Municipal Jalapa | - | Chinandega | 1:1 | ||||
| 10. Round | 27/09/2020 | Chinandega | - | Diriangén FC | 1:3 | ||||
| 13. Round | 26/10/2020 | Club Deportivo Ocotal | - | Chinandega | 1:2 | |
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| 14. Round | 28/10/2020 | Junior Managua | - | Chinandega | 0:1 | ||||
| 15. Round | 01/11/2020 | Chinandega | - | Real Madriz | 1:1 | |
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| 16. Round | 08/11/2020 | Juventus Managua | - | Chinandega | 5:1 | |
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| 17. Round | 15/11/2020 | Chinandega | - | ART Municipal Jalapa | 1:1 | ||||
| 18. Round | 20/11/2020 | CD Walter Ferretti | - | Chinandega | 4:0 |
Colombia