| 2. Round | 23/01/2022 | Marathón | - | Olimpia | 1:0 |  |
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| 3. Round | 06/02/2022 | Olimpia | - | Honduras Progreso | 3:0 |  |
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| 4. Round | 10/02/2022 | Vida | - | Olimpia | 0:3 | |
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| 5. Round | 13/02/2022 | Olimpia | - | Motagua | 1:1 | |
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| 6. Round | 20/02/2022 | Olimpia | - | Real España | 1:3 | |
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| 8. Round | 03/03/2022 | Platense | - | Olimpia | 0:3 | |
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| 9. Round | 06/03/2022 | Olimpia | - | Victoria | 0:1 |
Honduras