| 12. Round | 05/11/2021 | Cefn Druids | - | Newtown AFC | 0:5 | ||||
| 13. Round | 09/11/2021 | Newtown AFC | - | Bala Town | 3:3 | ||||
| 14. Round | 19/11/2021 | The New Saints | - | Newtown AFC | 2:0 | ||||
| 15. Round | 04/12/2021 | Newtown AFC | - | Barry Town United | 2:1 | ||||
| 16. Round | 10/12/2021 | Aberystwyth Town | - | Newtown AFC | 2:4 | ||||
| 17. Round | 18/12/2021 | Newtown AFC | - | Flint Town United | 2:0 | ||||
| 20. Round | 22/01/2022 | Newtown AFC | - | Haverfordwest County | 1:1 | ||||
| 21. Round | 28/01/2022 | Bala Town | - | Newtown AFC | 1:0 |  |
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| 19. Round | 12/02/2022 | Cardiff Metropolitan | - | Newtown AFC | 1:1 | ||||
| 18. Round | 19/02/2022 | Newtown AFC | - | Cardiff Metropolitan | 0:0 | ||||
| 22. Round | 26/02/2022 | Newtown AFC | - | Connah's Quay Nomads | 0:2 |
England