| 3. Round | 21/02/2016 | Peñarol | - | Defensor Sporting | 5:1 | ||||
| 4. Round | 28/02/2016 | Defensor Sporting | - | Danubio | 3:2 |  |
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| 5. Round | 06/03/2016 | Rentistas | - | Defensor Sporting | 0:1 | ||||
| 6. Round | 20/03/2016 | Defensor Sporting | - | Liverpool | 1:2 | |
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| 7. Round | 02/04/2016 | Villa Teresa | - | Defensor Sporting | 2:2 |  |
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| 9. Round | 23/04/2016 | Montevideo Wanderers | - | Defensor Sporting | 0:0 | |
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| 13. Round | 22/05/2016 | El Tanque Sisley | - | Defensor Sporting | 5:6 | ||||
| 14. Round | 29/05/2016 | River Plate | - | Defensor Sporting | 1:2 | |
Colombia