| 6. Round | 05/12/2020 | Maritzburg United | - | Mamelodi Sundowns | 1:1 | ||||
| 7. Round | 15/12/2020 | Mamelodi Sundowns | - | TS Galaxy | 2:0 | ||||
| 8. Round | 19/12/2020 | Golden Arrows | - | Mamelodi Sundowns | 1:1 | ||||
| 9. Round | 02/01/2021 | Mamelodi Sundowns | - | Orlando Pirates | 1:0 |  |
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| 10. Round | 09/01/2021 | Baroka FC | - | Mamelodi Sundowns | 0:2 | ||||
| 11. Round | 16/01/2021 | SuperSport United | - | Mamelodi Sundowns | 0:0 | ||||
| 12. Round | 19/01/2021 | Mamelodi Sundowns | - | Bloemfontein Celtic | 0:0 | |
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| 21. Round | 06/04/2021 | Tshakhuma FC | - | Mamelodi Sundowns | 1:3 | ||||
| 24. Round | 25/04/2021 | Mamelodi Sundowns | - | Kaizer Chiefs | 1:2 | ||||
| 26. Round | 02/05/2021 | Orlando Pirates | - | Mamelodi Sundowns | 0:3 | ||||
| 27. Round | 09/05/2021 | TS Galaxy | - | Mamelodi Sundowns | 0:1 | ||||
| 28. Round | 26/05/2021 | Mamelodi Sundowns | - | SuperSport United | 3:1 | ||||
| 30. Round | 05/06/2021 | Mamelodi Sundowns | - | Cape Town City FC | 3:0 |
Kenya