| 1. Round | 25/01/2021 | Club Deportivo Ocotal | - | Real Estelí FC | 0:1 | ||||
| 2. Round | 28/01/2021 | Chinandega | - | Real Estelí FC | 2:4 | ||||
| 3. Round | 01/02/2021 | Real Madriz | - | Real Estelí FC | 0:1 | ||||
| 4. Round | 05/02/2021 | Juventus Managua | - | Real Estelí FC | 0:1 | ||||
| 5. Round | 08/02/2021 | ART Municipal Jalapa | - | Real Estelí FC | 2:1 | ||||
| 6. Round | 11/02/2021 | CD Walter Ferretti | - | Real Estelí FC | 0:1 | ||||
| 7. Round | 14/02/2021 | Diriangén FC | - | Real Estelí FC | 1:0 |  |
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| 8. Round | 18/02/2021 | Real Estelí FC | - | Junior Managua | 7:0 |  |
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| 9. Round | 01/03/2021 | Real Estelí FC | - | Managua FC | 1:1 | ||||
| 10. Round | 07/03/2021 | Real Estelí FC | - | Club Deportivo Ocotal | 1:1 | |
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| 11. Round | 14/03/2021 | Real Estelí FC | - | Chinandega | 4:1 | ||||
| 12. Round | 01/04/2021 | Real Estelí FC | - | Real Madriz | 0:3 dec. | ||||
| 14. Round | 20/04/2021 | Real Estelí FC | - | ART Municipal Jalapa | 1:0 |
Brazil