| 10. Round | 02/10/2021 | Juventus Managua | - | Managua FC | 1:3 | ||||
| 13. Round | 21/10/2021 | Real Estelí FC | - | Juventus Managua | 3:0 |  |
|||
| 14. Round | 23/10/2021 | H&H Export Sébaco | - | Juventus Managua | 3:3 | |
|||
| 15. Round | 01/11/2021 | Club Deportivo Ocotal | - | Juventus Managua | 1:0 | ||||
| 16. Round | 03/11/2021 | Juventus Managua | - | CD Walter Ferretti | 2:2 | ||||
| 17. Round | 19/11/2021 | ART Municipal Jalapa | - | Juventus Managua | 1:1 | ||||
| 18. Round | 21/11/2021 | Juventus Managua | - | UNAN Managua | 1:2 |
Brazil