| 1. Round | 20/11/2021 | Perth Glory | - | Adelaide United | 1:1 |  |
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| 2. Round | 26/11/2021 | Western United | - | Perth Glory | 1:0 | ||||
| 3. Round | 05/12/2021 | Melbourne Victory | - | Perth Glory | 0:3 | |
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| 4. Round | 08/12/2021 | Melbourne City FC | - | Perth Glory | 1:0 | |
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| 5. Round | 19/01/2022 | Brisbane Roar | - | Perth Glory | 1:0 | ||||
| 7. Round | 22/01/2022 | Sydney FC | - | Perth Glory | 1:2 | |
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| 14. Round | 13/02/2022 | Central Coast Mariners | - | Perth Glory | 1:1 | ||||
| 15. Round | 20/02/2022 | Perth Glory | - | Brisbane Roar | 2:0 | |
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| 12. Round | 23/02/2022 | Perth Glory | - | Macarthur FC | 0:1 | ||||
| 16. Round | 27/02/2022 | Perth Glory | - | Western United | 0:2 | ||||
| 13. Round | 02/03/2022 | Melbourne City FC | - | Perth Glory | 2:2 | |
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| 17. Round | 06/03/2022 | Perth Glory | - | Adelaide United | 1:2 | |
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| 26. Round | 12/03/2022 | Perth Glory | - | Sydney FC | 0:2 | |
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| 18. Round | 15/03/2022 | Perth Glory | - | Central Coast Mariners | 0:0 | ||||
| 19. Round | 19/03/2022 | Perth Glory | - | Brisbane Roar | 1:4 | ||||
| 21. Round | 30/04/2022 | Perth Glory | - | Western Sydney Wanderers | 1:1 | |
Uruguay
