| 17. Round | 20/02/2022 | Dinamo Zagreb II | - | NK Osijek II | 2:1 | ||||
| 18. Round | 26/02/2022 | NK Osijek II | - | NK Dugopolje | 2:0 | ||||
| 19. Round | 05/03/2022 | NK Solin | - | NK Osijek II | 0:0 | ||||
| 20. Round | 14/03/2022 | NK Osijek II | - | NK Dubrava | 0:1 | ||||
| 21. Round | 20/03/2022 | NK Croatia Zmijavci | - | NK Osijek II | 1:0 | ||||
| 22. Round | 04/04/2022 | NK Osijek II | - | HNK Orijent Rijeka | 1:0 | ||||
| 23. Round | 09/04/2022 | NK Opatija | - | NK Osijek II | 1:2 | ||||
| 24. Round | 15/04/2022 | NK Osijek II | - | HNK Cibalia | 2:1 | ||||
| 25. Round | 23/04/2022 | NK Varaždin | - | NK Osijek II | 4:1 | ||||
| 27. Round | 07/05/2022 | NK Rudeš | - | NK Osijek II | 1:0 | ||||
| 28. Round | 16/05/2022 | NK Osijek II | - | NK Kustošija | 0:1 |  |
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| 29. Round | 21/05/2022 | NK Jarun | - | NK Osijek II | 3:0 | ||||
| 30. Round | 28/05/2022 | NK Osijek II | - | NK BSK Bijelo Brdo | 1:1 | |
Croatia