| 1. Round | 26/01/2019 | Patriotas FC | - | Independiente Medellín | 2:1 | ||||
| 2. Round | 30/01/2019 | Independiente Medellín | - | La Equidad | 1:1 | ||||
| 3. Round | 02/02/2019 | Atlético Junior | - | Independiente Medellín | 3:2 | ||||
| 4. Round | 10/02/2019 | Independiente Medellín | - | Unión Magdalena | 1:1 | ||||
| 6. Round | 24/02/2019 | Independiente Medellín | - | Deportivo Cali | 1:1 | ||||
| 7. Round | 28/02/2019 | Águilas Doradas | - | Independiente Medellín | 0:1 | ||||
| 9. Round | 10/03/2019 | Independiente Medellín | - | Santa Fe | 1:0 | ||||
| 10. Round | 16/03/2019 | Independiente Medellín | - | Atlético Nacional | 2:2 | ||||
| 15. Round | 14/04/2019 | Independiente Medellín | - | Atlético Bucaramanga | 4:0 | ||||
| 17. Round | 20/04/2019 | Independiente Medellín | - | Jaguares de Córdoba | 3:0 | ||||
| 18. Round | 28/04/2019 | Alianza Petrolera | - | Independiente Medellín | 1:1 | ||||
| 20. Round | 05/05/2019 | Deportes Tolima | - | Independiente Medellín | 0:1 |
Colombia