| 2. Round | 16/01/2022 | LD Alajuelense | - | Guadalupe | 1:0 | ||||
| 3. Round | 22/01/2022 | LD Alajuelense | - | AD Guanacasteca | 4:0 | ||||
| 4. Round | 04/02/2022 | Municipal Pérez Zeledón | - | LD Alajuelense | 2:1 | ||||
| 5. Round | 10/02/2022 | LD Alajuelense | - | CS Cartaginés | 3:2 | ||||
| 12. Round | 06/04/2022 | LD Alajuelense | - | Sporting FC | 1:1 | ||||
| 21. Round | 13/05/2022 | LD Alajuelense | - | AD San Carlos | 1:0 |  |
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| 22. Round | 16/05/2022 | Santos de Guápiles | - | LD Alajuelense | 2:0 |
Honduras