| 9. Round | 03/03/2021 | Real Santander | - | Orsomarso SC | 1:2 | ||||
| 10. Round | 07/03/2021 | Orsomarso SC | - | Bogotá FC | 4:2 | ||||
| 11. Round | 14/03/2021 | Fortaleza FC | - | Orsomarso SC | 3:1 | ||||
| 12. Round | 22/03/2021 | Orsomarso SC | - | Leones FC | 1:1 |  |
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| 13. Round | 27/03/2021 | Atlético Huila | - | Orsomarso SC | 3:2 | ||||
| 15. Round | 09/04/2021 | Atlético FC | - | Orsomarso SC | 0:0 |
Colombia