| 1. Round | 16/01/2022 | Alianza | - | Isidro Metapán | 0:2 | ||||
| 2. Round | 23/01/2022 | Isidro Metapán | - | AD Chalatenango | 2:1 | ||||
| 20. Round | 28/04/2022 | Isidro Metapán | - | Santa Tecla FC | 0:0 | ||||
| 21. Round | 01/05/2022 | Municipal Limeño | - | Isidro Metapán | 1:0 | ||||
| 22. Round | 07/05/2022 | Isidro Metapán | - | Atlético Marte | 1:1 |  |
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El Salvador