| 16. Round | 24/01/2021 | Lommel SK | - | RWD Molenbeek | 3:2 | ||||
| 17. Round | 30/01/2021 | RWD Molenbeek | - | Union Saint-Gilloise | 0:2 | ||||
| 20. Round | 20/02/2021 | RWD Molenbeek | - | KVC Westerlo | 2:1 | ||||
| 21. Round | 26/02/2021 | Club NXT | - | RWD Molenbeek | 1:3 | ||||
| 22. Round | 06/03/2021 | RWD Molenbeek | - | KMSK Deinze | 1:1 | ||||
| 23. Round | 13/03/2021 | Union Saint-Gilloise | - | RWD Molenbeek | 2:1 |  |
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| 18. Round | 18/03/2021 | KMSK Deinze | - | RWD Molenbeek | 4:4 | ||||
| 24. Round | 21/03/2021 | RFC Seraing | - | RWD Molenbeek | 1:0 | ||||
| 25. Round | 02/04/2021 | RWD Molenbeek | - | Club NXT | 1:1 | ||||
| 26. Round | 09/04/2021 | KVC Westerlo | - | RWD Molenbeek | 2:2 | ||||
| 27. Round | 17/04/2021 | RWD Molenbeek | - | Lommel SK | 2:5 | ||||
| 28. Round | 25/04/2021 | Lierse Kempenzonen | - | RWD Molenbeek | 0:3 |
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