| 1. Round | 21/07/2022 | CS Cartaginés | - | Municipal Grecia | 1:2 | ||||
| 2. Round | 24/07/2022 | CS Cartaginés | - | Puntarenas FC | 1:3 | ||||
| 3. Round | 31/07/2022 | AD San Carlos | - | CS Cartaginés | 1:1 | ||||
| 5. Round | 12/08/2022 | Municipal Pérez Zeledón | - | CS Cartaginés | 2:1 | ||||
| 6. Round | 14/08/2022 | Municipal Grecia | - | CS Cartaginés | 3:5 | ||||
| 9. Round | 02/09/2022 | CS Cartaginés | - | Municipal Pérez Zeledón | 2:1 | ||||
| 10. Round | 04/09/2022 | CS Cartaginés | - | AD San Carlos | 3:2 | ||||
| 12. Round | 18/09/2022 | CS Cartaginés | - | Guadalupe | 3:0 | ||||
| 16. Round | 02/10/2022 | AD Guanacasteca | - | CS Cartaginés | 1:1 |  |
Nicaragua