| 1. Round | 24/07/2021 | FC Lausanne-Sport | - | FC St. Gallen | 1:2 |  |
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| 2. Round | 31/07/2021 | FC Zürich | - | FC Lausanne-Sport | 3:1 | |
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| 3. Round | 07/08/2021 | Grasshopper Club Zürich | - | FC Lausanne-Sport | 3:1 | ||||
| 4. Round | 22/08/2021 | FC Lausanne-Sport | - | FC Basel 1893 | 2:2 | ||||
| 5. Round | 29/08/2021 | FC Luzern | - | FC Lausanne-Sport | 1:1 | ||||
| 6. Round | 12/09/2021 | FC Lausanne-Sport | - | FC Sion | 1:1 | ||||
| 7. Round | 22/09/2021 | FC Lausanne-Sport | - | BSC Young Boys | 1:6 | ||||
| 8. Round | 25/09/2021 | Servette FC | - | FC Lausanne-Sport | 1:1 | ||||
| 9. Round | 02/10/2021 | FC Lugano | - | FC Lausanne-Sport | 2:0 | ||||
| 10. Round | 17/10/2021 | FC Lausanne-Sport | - | Grasshopper Club Zürich | 3:1 |  |
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| 11. Round | 23/10/2021 | BSC Young Boys | - | FC Lausanne-Sport | 3:2 | |
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| 13. Round | 07/11/2021 | FC Lausanne-Sport | - | FC Lugano | 0:2 | ||||
| 14. Round | 21/11/2021 | FC St. Gallen | - | FC Lausanne-Sport | 0:1 | ||||
| 15. Round | 28/11/2021 | FC Lausanne-Sport | - | Servette FC | 0:3 |  |
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| 17. Round | 11/12/2021 | FC Lausanne-Sport | - | FC Zürich | 1:3 | ||||
| 18. Round | 19/12/2021 | FC Sion | - | FC Lausanne-Sport | 2:0 |
Switzerland
Spain