| 1. Round | 11/09/2021 | Cerro Largo | - | Nacional | 0:3 dec. | ||||
| 2. Round | 19/09/2021 | Nacional | - | Progreso | 0:1 | ||||
| 3. Round | 25/09/2021 | Sud América | - | Nacional | 0:2 | ||||
| 4. Round | 03/10/2021 | Nacional | - | Plaza Colonia | 2:1 |  |
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| 5. Round | 10/10/2021 | Fénix | - | Nacional | 1:2 | ||||
| 6. Round | 16/10/2021 | Nacional | - | Boston River | 3:2 | ||||
| 7. Round | 22/10/2021 | Montevideo Wanderers | - | Nacional | 1:0 |  |
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| 8. Round | 25/10/2021 | Nacional | - | Rentistas | 2:2 | ||||
| 9. Round | 31/10/2021 | Peñarol | - | Nacional | 0:0 | ||||
| 10. Round | 04/11/2021 | Nacional | - | Montevideo City Torque | 2:0 | ||||
| 13. Round | 19/11/2021 | Nacional | - | Cerrito | 1:0 | |
Uruguay
Italy