| 1. Round | 30/07/2022 | Deportivo Maldonado | - | Nacional | 2:1 | ||||
| 2. Round | 06/08/2022 | Nacional | - | Rentistas | 3:0 | ||||
| 3. Round | 14/08/2022 | Liverpool | - | Nacional | 0:1 |  |
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| 6. Round | 20/08/2022 | Nacional | - | Montevideo Wanderers | 2:0 | ||||
| 5. Round | 27/08/2022 | Montevideo City Torque | - | Nacional | 0:3 | ||||
| 4. Round | 04/09/2022 | Nacional | - | Peñarol | 3:1 |  |
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| 7. Round | 10/09/2022 | Plaza Colonia | - | Nacional | 1:3 | ||||
| 8. Round | 15/09/2022 | Nacional | - | Boston River | 1:0 | |
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| 9. Round | 17/09/2022 | River Plate | - | Nacional | 1:1 | ||||
| 10. Round | 25/09/2022 | Nacional | - | Cerro Largo | 1:1 | ||||
| 11. Round | 01/10/2022 | Fénix | - | Nacional | 1:1 | ||||
| 12. Round | 08/10/2022 | Nacional | - | Defensor Sporting | 1:1 | |
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| 13. Round | 13/10/2022 | Albion | - | Nacional | 0:1 | |
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| 14. Round | 18/10/2022 | Cerrito | - | Nacional | 1:2 | |
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