| 2. Round | 15/08/2010 | Real Esppor Club | - | Zamora FC | 3:0 | ||||
| 3. Round | 22/08/2010 | Deportivo Lara | - | Real Esppor Club | 1:3 | ||||
| 4. Round | 30/08/2010 | Real Esppor Club | - | Atlético El Vigía | 2:0 |  |
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| 5. Round | 11/09/2010 | Zulia FC | - | Real Esppor Club | 2:5 | ||||
| 6. Round | 19/09/2010 | Real Esppor Club | - | Aragua FC | 3:0 | |
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| 7. Round | 23/09/2010 | Estudiantes de Mérida | - | Real Esppor Club | 1:0 |  |
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| 8. Round | 03/10/2010 | Deportivo Petare | - | Real Esppor Club | 0:0 | ||||
| 9. Round | 16/10/2010 | Real Esppor Club | - | Deportivo Anzoátegui | 3:0 | |
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| 10. Round | 24/10/2010 | Caroni FC | - | Real Esppor Club | 0:1 | ||||
| 1. Round | 28/10/2010 | Mineros de Guayana | - | Real Esppor Club | 1:3 | |
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| 11. Round | 31/10/2010 | Real Esppor Club | - | Monagas | 2:1 | ||||
| 12. Round | 07/11/2010 | Atlético Venezuela | - | Real Esppor Club | 0:1 | |
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| 13. Round | 14/11/2010 | Real Esppor Club | - | Caracas FC | 1:2 | ||||
| 14. Round | 20/11/2010 | Carabobo FC | - | Real Esppor Club | 0:0 | ||||
| 15. Round | 28/11/2010 | Real Esppor Club | - | Trujillanos FC | 1:1 | ||||
| 16. Round | 05/12/2010 | Deportivo Táchira | - | Real Esppor Club | 2:0 |  |
Colombia