| 1. Round | 08/08/2021 | Vida | - | Lobos UPNFM | 1:1 | ||||
| 2. Round | 12/08/2021 | Real Sociedad | - | Vida | 3:3 | ||||
| 3. Round | 15/08/2021 | Olimpia | - | Vida | 1:1 | ||||
| 4. Round | 22/08/2021 | Vida | - | Marathón | 2:0 | ||||
| 5. Round | 26/08/2021 | Vida | - | Victoria | 2:0 | ||||
| 6. Round | 29/08/2021 | Honduras Progreso | - | Vida | 1:1 | ||||
| 7. Round | 05/09/2021 | Vida | - | Real España | 1:0 | ||||
| 8. Round | 12/09/2021 | Platense | - | Vida | 1:4 |  |
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| 9. Round | 16/09/2021 | Motagua | - | Vida | 2:1 |  |
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| 12. Round | 03/10/2021 | Vida | - | Real Sociedad | 2:1 | ||||
| 13. Round | 10/10/2021 | Lobos UPNFM | - | Vida | 0:0 | |
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| 14. Round | 17/10/2021 | Vida | - | Olimpia | 2:1 | ||||
| 15. Round | 24/10/2021 | Victoria | - | Vida | 1:2 | ||||
| 16. Round | 28/10/2021 | Vida | - | Motagua | 1:1 | ||||
| 17. Round | 31/10/2021 | Vida | - | Platense | 3:1 | |
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| 18. Round | 10/11/2021 | Real España | - | Vida | 2:1 |
Honduras