| 3. Round | 01/02/2022 | Deportes Tolima | - | Unión Magdalena | 2:1 | ||||
| 4. Round | 03/02/2022 | Unión Magdalena | - | Deportivo Pasto | 0:0 |  |
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| 7. Round | 15/02/2022 | Unión Magdalena | - | Atlético Bucaramanga | 0:3 dec. | |
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| 8. Round | 20/02/2022 | Atlético Nacional | - | Unión Magdalena | 1:0 | ||||
| 11. Round | 18/03/2022 | Unión Magdalena | - | Cortuluá | 0:2 | ||||
| 12. Round | 21/03/2022 | Jaguares de Córdoba | - | Unión Magdalena | 2:0 |
Colombia