| 5. Round | 06/02/2021 | Junior Managua | - | Chinandega | 2:1 |  |
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| 7. Round | 15/02/2021 | Junior Managua | - | Real Madriz | 1:0 | ||||
| 9. Round | 01/03/2021 | Junior Managua | - | Juventus Managua | 1:2 | |
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| 10. Round | 07/03/2021 | Managua FC | - | Junior Managua | 3:1 | ||||
| 11. Round | 14/03/2021 | Junior Managua | - | ART Municipal Jalapa | 2:1 | |
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| 12. Round | 01/04/2021 | Club Deportivo Ocotal | - | Junior Managua | 2:1 | ||||
| 13. Round | 11/04/2021 | Junior Managua | - | CD Walter Ferretti | 1:1 | ||||
| 14. Round | 18/04/2021 | Chinandega | - | Junior Managua | 2:1 | ||||
| 15. Round | 25/04/2021 | Junior Managua | - | Diriangén FC | 0:1 | ||||
| 16. Round | 29/04/2021 | Real Madriz | - | Junior Managua | 1:2 | ||||
| 17. Round | 02/05/2021 | Junior Managua | - | Real Estelí FC | 0:2 |
Nicaragua