| 1. Round | 10/07/2022 | Mannucci | - | FBC Melgar | 0:1 | ||||
| 2. Round | 17/07/2022 | FBC Melgar | - | Sporting Cristal | 0:1 | ||||
| 3. Round | 24/07/2022 | FBC Melgar | - | Sport Huancayo | 1:0 | ||||
| 5. Round | 29/07/2022 | FBC Melgar | - | Universidad Técnica | 1:0 | ||||
| 7. Round | 16/08/2022 | FBC Melgar | - | Academia Cantolao | 3:1 | ||||
| 8. Round | 21/08/2022 | Carlos Stein | - | FBC Melgar | 0:2 | ||||
| 9. Round | 27/08/2022 | FBC Melgar | - | Universidad San Martín | 2:1 | ||||
| 11. Round | 12/09/2022 | FBC Melgar | - | Deportivo Municipal | 6:2 | ||||
| 12. Round | 17/09/2022 | Cienciano | - | FBC Melgar | 2:2 | ||||
| 6. Round | 22/09/2022 | Alianza Lima | - | FBC Melgar | 2:0 | ||||
| 10. Round | 24/09/2022 | Universidad Cesar Vallejo | - | FBC Melgar | 3:2 | ||||
| 13. Round | 29/09/2022 | FBC Melgar | - | Deportivo Binacional | 2:1 | ||||
| 14. Round | 05/10/2022 | AD Tarma | - | FBC Melgar | 1:1 | ||||
| 15. Round | 09/10/2022 | FBC Melgar | - | Ayacucho FC | 3:0 | ||||
| 16. Round | 16/10/2022 | Universitario de Deportes | - | FBC Melgar | 1:1 |  |
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| 17. Round | 19/10/2022 | FBC Melgar | - | Sport Boys | 3:0 | ||||
| 18. Round | 24/10/2022 | Atlético Grau | - | FBC Melgar | 2:1 | ||||
| 19. Round | 30/10/2022 | FBC Melgar | - | Alianza Atlético | 0:1 |
Peru