| 3. Round | 08/08/2021 | Barranquilla FC | - | Atlético FC | 1:1 |  |
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| 4. Round | 16/08/2021 | Orsomarso SC | - | Barranquilla FC | 0:0 | ||||
| 5. Round | 26/08/2021 | Barranquilla FC | - | Valledupar FC | 2:1 | ||||
| 6. Round | 01/09/2021 | Boyacá Chicó | - | Barranquilla FC | 1:1 | ||||
| 7. Round | 04/09/2021 | Barranquilla FC | - | Fortaleza FC | 0:0 | ||||
| 8. Round | 11/09/2021 | Real Santander | - | Barranquilla FC | 1:1 |
Colombia