| 2. Round | 14/07/2022 | Atlético Junior | - | Atlético Nacional | 3:1 |  |
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| 5. Round | 31/07/2022 | Águilas Doradas | - | Atlético Junior | 1:1 | ||||
| 7. Round | 14/08/2022 | Atlético Junior | - | Independiente Medellín | 4:2 | ||||
| 8. Round | 21/08/2022 | América de Cali | - | Atlético Junior | 2:1 | ||||
| 12. Round | 18/09/2022 | Deportivo Pasto | - | Atlético Junior | 2:1 | ||||
| 14. Round | 26/09/2022 | Alianza Petrolera | - | Atlético Junior | 0:1 | ||||
| 20. Round | 30/10/2022 | Jaguares de Córdoba | - | Atlético Junior | 0:2 |  |
Colombia