| 3. Round | 30/01/2022 | Deportivo Malacateco | - | Cobán Imperial | 0:0 |  |
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| 5. Round | 05/02/2022 | Nueva Concepción | - | Cobán Imperial | 1:2 | ||||
| 6. Round | 10/02/2022 | Antigua GFC | - | Cobán Imperial | 0:1 | ||||
| 7. Round | 12/02/2022 | Cobán Imperial | - | Iztapa | 2:0 | |
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| 15. Round | 03/04/2022 | Xelaju MC | - | Cobán Imperial | 2:2 | ||||
| 18. Round | 20/04/2022 | Iztapa | - | Cobán Imperial | 3:0 | |
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| 21. Round | 04/05/2022 | Cobán Imperial | - | Santa Lucía | 1:0 | ||||
| 22. Round | 08/05/2022 | Deportivo Guastatoya | - | Cobán Imperial | 4:0 |
Guatemala