| 1. Round | 23/01/2022 | Club Deportivo Ocotal | - | ART Municipal Jalapa | 0:1 | ||||
| 2. Round | 06/02/2022 | Club Deportivo Ocotal | - | CD Walter Ferretti | 1:0 | ||||
| 3. Round | 11/02/2022 | Club Deportivo Ocotal | - | H&H Export Sébaco | 0:0 | ||||
| 4. Round | 14/02/2022 | Diriangén FC | - | Club Deportivo Ocotal | 2:0 | ||||
| 5. Round | 21/02/2022 | Club Deportivo Ocotal | - | Real Madriz | 2:0 |  |
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| 6. Round | 28/02/2022 | Club Deportivo Ocotal | - | Juventus Managua | 0:1 | ||||
| 7. Round | 03/03/2022 | Managua FC | - | Club Deportivo Ocotal | 1:1 | ||||
| 8. Round | 06/03/2022 | UNAN Managua | - | Club Deportivo Ocotal | 2:1 | ||||
| 12. Round | 03/04/2022 | H&H Export Sébaco | - | Club Deportivo Ocotal | 4:1 | ||||
| 13. Round | 07/04/2022 | Club Deportivo Ocotal | - | Diriangén FC | 1:0 | ||||
| 14. Round | 10/04/2022 | Real Madriz | - | Club Deportivo Ocotal | 0:1 | ||||
| 15. Round | 14/04/2022 | Club Deportivo Ocotal | - | Managua FC | 1:1 | ||||
| 16. Round | 25/04/2022 | Juventus Managua | - | Club Deportivo Ocotal | 2:1 |
Nicaragua