| 1. Round | 10/07/2022 | Managua FC | - | Club Deportivo Ocotal | 3:1 | ||||
| 2. Round | 17/07/2022 | Club Deportivo Ocotal | - | Real Estelí FC | 0:1 | ||||
| 3. Round | 24/07/2022 | Club Deportivo Ocotal | - | Diriangén FC | 1:1 | ||||
| 5. Round | 07/08/2022 | Club Deportivo Ocotal | - | Matagalpa FC | 1:1 | ||||
| 6. Round | 11/08/2022 | Club Deportivo Ocotal | - | H&H Export Sébaco | 2:1 | ||||
| 7. Round | 14/08/2022 | ART Municipal Jalapa | - | Club Deportivo Ocotal | 0:3 dec. | ||||
| 10. Round | 04/09/2022 | Club Deportivo Ocotal | - | Managua FC | 2:1 | ||||
| 11. Round | 11/09/2022 | Real Estelí FC | - | Club Deportivo Ocotal | 5:0 | ||||
| 14. Round | 27/10/2022 | Matagalpa FC | - | Club Deportivo Ocotal | 1:0 | ||||
| 15. Round | 30/10/2022 | H&H Export Sébaco | - | Club Deportivo Ocotal | 2:0 | ||||
| 16. Round | 13/11/2022 | Club Deportivo Ocotal | - | ART Municipal Jalapa | 2:3 | ||||
| 17. Round | 27/11/2022 | Club Deportivo Ocotal | - | CD Walter Ferretti | 1:1 |
Nicaragua