| 1. Round | 24/01/2021 | Juventus Managua | - | ART Municipal Jalapa | 3:1 | ||||
| 2. Round | 28/01/2021 | CD Walter Ferretti | - | Juventus Managua | 1:0 | ||||
| 3. Round | 31/01/2021 | Juventus Managua | - | Diriangén FC | 1:0 | ||||
| 4. Round | 05/02/2021 | Juventus Managua | - | Real Estelí FC | 0:1 | ||||
| 10. Round | 08/03/2021 | ART Municipal Jalapa | - | Juventus Managua | 1:0 | ||||
| 17. Round | 02/05/2021 | Juventus Managua | - | Real Madriz | 0:0 |
Nicaragua