| 2. Round | 15/08/2010 | Real Esppor Club | - | Zamora FC | 3:0 |  |
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| 3. Round | 22/08/2010 | Deportivo Lara | - | Real Esppor Club | 1:3 | ||||
| 4. Round | 30/08/2010 | Real Esppor Club | - | Atlético El Vigía | 2:0 | ||||
| 6. Round | 19/09/2010 | Real Esppor Club | - | Aragua FC | 3:0 | ||||
| 8. Round | 03/10/2010 | Deportivo Petare | - | Real Esppor Club | 0:0 | ||||
| 9. Round | 16/10/2010 | Real Esppor Club | - | Deportivo Anzoátegui | 3:0 | ||||
| 12. Round | 07/11/2010 | Atlético Venezuela | - | Real Esppor Club | 0:1 | ||||
| 14. Round | 20/11/2010 | Carabobo FC | - | Real Esppor Club | 0:0 | ||||
| 15. Round | 28/11/2010 | Real Esppor Club | - | Trujillanos FC | 1:1 | ||||
| 17. Round | 12/12/2010 | Real Esppor Club | - | Yaracuyanos FC | 2:0 | |
Venezuela