2. Round | 12/08/2021 | Olimpia | - | Real España | 1:1 | ||||
3. Round | 15/08/2021 | Platense | - | Real España | 0:2 | ||||
4. Round | 22/08/2021 | Real España | - | Real Sociedad | 1:1 | ||||
5. Round | 26/08/2021 | Real España | - | Lobos UPNFM | 5:3 | ||||
6. Round | 29/08/2021 | Marathón | - | Real España | 0:1 | ||||
7. Round | 05/09/2021 | Vida | - | Real España | 1:0 | ||||
16. Round | 28/10/2021 | Real España | - | Honduras Progreso | 4:1 |