1. Round | 20/01/2022 | Victoria | - | Real España | 4:1 | ||||
3. Round | 06/02/2022 | Real España | - | Motagua | 1:2 | ||||
8. Round | 03/03/2022 | Real España | - | Lobos UPNFM | 1:0 | ||||
9. Round | 06/03/2022 | Vida | - | Real España | 0:1 | ||||
10. Round | 13/03/2022 | Motagua | - | Real España | 0:2 | ||||
11. Round | 20/03/2022 | Real España | - | Platense | 3:2 | ||||
13. Round | 07/04/2022 | Real Sociedad | - | Real España | 0:3 | ||||
14. Round | 11/04/2022 | Real España | - | Olimpia | 1:0 | ||||
15. Round | 14/04/2022 | Lobos UPNFM | - | Real España | 0:2 | ||||
16. Round | 21/04/2022 | Real España | - | Victoria | 3:1 | ||||
17. Round | 24/04/2022 | Honduras Progreso | - | Real España | 1:1 | ||||
12. Round | 28/04/2022 | Real España | - | Marathón | 3:1 | ||||
18. Round | 01/05/2022 | Real España | - | Vida | 1:4 |