| 2. Round | 09/02/2025 | Real Cartagena | - | Bogotá FC | 5:0 | ||||
| 3. Round | 17/02/2025 | Leones FC | - | Real Cartagena | 1:2 | ||||
| 5. Round | 02/03/2025 | Real Cartagena | - | Boca Juniors de Cali | 3:2 | ||||
| 7. Round | 18/03/2025 | Tigres FC | - | Real Cartagena | 0:0 |  |
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| 9. Round | 29/03/2025 | Barranquilla FC | - | Real Cartagena | 2:2 | ||||
| 13. Round | 25/04/2025 | Atlético FC | - | Real Cartagena | 1:2 | ||||
| 8. Round | 01/05/2025 | Real Cartagena | - | Atlético Huila | 1:1 | ||||
| 14. Round | 07/05/2025 | Real Cartagena | - | Barranquilla FC | 3:0 | ||||
| 15. Round | 11/05/2025 | Cúcuta Deportivo | - | Real Cartagena | 1:1 |
Colombia