| 2. Round | 24/07/2010 | Club Rubio Ñu | - | Sport Colombia | 1:0 | ||||
| 3. Round | 01/08/2010 | Sport Colombia | - | Libertad | 1:0 |  |
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| 4. Round | 07/08/2010 | 3 de Febrero | - | Sport Colombia | 0:3 | |
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| 6. Round | 21/08/2010 | Sport Colombia | - | Tacuary | 1:3 | ||||
| 7. Round | 29/08/2010 | Sport Colombia | - | Club Nacional | 1:2 | ||||
| 8. Round | 05/09/2010 | Sol de América | - | Sport Colombia | 1:2 | ||||
| 9. Round | 12/09/2010 | Sport Colombia | - | Sportivo Trinidense | 1:1 | |
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| 10. Round | 19/09/2010 | Sportivo Luqueño | - | Sport Colombia | 1:1 | ||||
| 11. Round | 26/09/2010 | Cerro Porteño | - | Sport Colombia | 0:0 | ||||
| 12. Round | 03/10/2010 | Sport Colombia | - | Club Olimpia | 0:0 | ||||
| 13. Round | 10/10/2010 | Sport Colombia | - | Club Rubio Ñu | 2:0 | ||||
| 14. Round | 16/10/2010 | Libertad | - | Sport Colombia | 4:0 | ||||
| 15. Round | 20/10/2010 | Sport Colombia | - | 3 de Febrero | 1:1 | ||||
| 17. Round | 30/10/2010 | Tacuary | - | Sport Colombia | 2:1 | ||||
| 18. Round | 06/11/2010 | Club Nacional | - | Sport Colombia | 4:3 | ||||
| 19. Round | 14/11/2010 | Sport Colombia | - | Sol de América | 2:0 | |
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| 21. Round | 28/11/2010 | Sport Colombia | - | Sportivo Luqueño | 0:0 | ||||
| 22. Round | 05/12/2010 | Sport Colombia | - | Cerro Porteño | 1:1 |
Paraguay