| 1. Round | 20/05/2021 | Unión Huaral | - | Santos FC | 1:3 | ||||
| 2. Round | 26/05/2021 | Santos FC | - | Chavelines Juniors | 2:1 |  |
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| 3. Round | 30/05/2021 | Deportivo Coopsol | - | Santos FC | 1:0 | ||||
| 5. Round | 26/06/2021 | Pirata | - | Santos FC | 2:2 | ||||
| 6. Round | 03/07/2021 | Santos FC | - | Comerciantes Unidos | 4:2 | |
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| 7. Round | 08/07/2021 | Atlético Grau | - | Santos FC | 4:1 | |
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| 8. Round | 12/07/2021 | Unión Comercio | - | Santos FC | 0:2 | |
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| 9. Round | 16/07/2021 | Santos FC | - | Llacuabamba | 0:1 | ||||
| 10. Round | 22/07/2021 | Cultural Santa Rosa | - | Santos FC | 3:0 | ||||
| 11. Round | 29/07/2021 | Santos FC | - | Carlos Stein | 1:1 |
Colombia