| 2. Round | 10/04/2022 | Santos FC | - | Deportivo Coopsol | 2:2 | ||||
| 3. Round | 17/04/2022 | Unión Huaral | - | Santos FC | 0:0 |  |
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| 4. Round | 24/04/2022 | Santos FC | - | Juan Aurich | 4:0 | ||||
| 5. Round | 01/05/2022 | Alianza Universidad | - | Santos FC | 4:1 |  |
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| 8. Round | 22/05/2022 | Santos FC | - | Cusco FC | 1:2 | ||||
| 9. Round | 29/05/2022 | Alfonso Ugarte | - | Santos FC | 1:1 | ||||
| 11. Round | 11/06/2022 | Pirata | - | Santos FC | 0:1 | ||||
| 12. Round | 19/06/2022 | Santos FC | - | Llacuabamba | 2:2 | |
Peru