| 8. Round | 12/09/2021 | FCSB | - | Dinamo Bucureşti | 6:0 |  |
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| 9. Round | 19/09/2021 | Dinamo Bucureşti | - | FC Botoşani | 1:2 | ||||
| 10. Round | 27/09/2021 | CS Universitatea Craiova | - | Dinamo Bucureşti | 5:0 | ||||
| 11. Round | 02/10/2021 | Dinamo Bucureşti | - | UTA Arad | 2:2 | ||||
| 12. Round | 15/10/2021 | Gaz Metan Mediaş | - | Dinamo Bucureşti | 2:1 | ||||
| 13. Round | 23/10/2021 | Dinamo Bucureşti | - | Rapid Bucureşti | 1:1 | ||||
| 14. Round | 31/10/2021 | Sepsi OSK | - | Dinamo Bucureşti | 4:1 | ||||
| 16. Round | 22/11/2021 | FC Voluntari | - | Dinamo Bucureşti | 2:1 | ||||
| 17. Round | 26/11/2021 | Dinamo Bucureşti | - | FC Universitatea Craiova | 0:0 | ||||
| 18. Round | 03/12/2021 | Academica Clinceni | - | Dinamo Bucureşti | 1:0 | ||||
| 19. Round | 13/12/2021 | Dinamo Bucureşti | - | Chindia Târgoviște | 1:0 | ||||
| 20. Round | 16/12/2021 | CS Mioveni | - | Dinamo Bucureşti | 2:1 | ||||
| 21. Round | 20/12/2021 | Dinamo Bucureşti | - | Farul Constanța | 0:2 |
Romania