| 1. Round | 23/07/2022 | CSD Municipal | - | Cobán Imperial | 1:4 |  |
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| 2. Round | 31/07/2022 | Achuapa | - | CSD Municipal | 1:0 | ||||
| 3. Round | 07/08/2022 | CSD Municipal | - | Iztapa | 1:0 | ||||
| 4. Round | 11/08/2022 | Antigua GFC | - | CSD Municipal | 0:3 |  |
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| 5. Round | 13/08/2022 | CSD Municipal | - | Deportivo Malacateco | 4:1 | ||||
| 6. Round | 21/08/2022 | Comunicaciones | - | CSD Municipal | 2:2 | |
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| 7. Round | 28/08/2022 | CSD Municipal | - | Deportivo Guastatoya | 0:0 | ||||
| 8. Round | 01/09/2022 | Deportivo Mixco | - | CSD Municipal | 1:4 | ||||
| 9. Round | 03/09/2022 | CSD Municipal | - | Xelaju MC | 1:1 | ||||
| 10. Round | 11/09/2022 | Santa Lucía | - | CSD Municipal | 1:0 | ||||
| 11. Round | 17/09/2022 | CSD Municipal | - | Deportivo Xinabajul | 2:0 | |
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| 13. Round | 01/10/2022 | CSD Municipal | - | Achuapa | 1:1 | ||||
| 14. Round | 09/10/2022 | Iztapa | - | CSD Municipal | 3:2 | ||||
| 15. Round | 16/10/2022 | CSD Municipal | - | Antigua GFC | 0:1 | ||||
| 17. Round | 29/10/2022 | CSD Municipal | - | Comunicaciones | 2:3 | ||||
| 16. Round | 09/11/2022 | Deportivo Malacateco | - | CSD Municipal | 1:0 | ||||
| 21. Round | 23/11/2022 | CSD Municipal | - | Santa Lucía | 2:0 | |
Guatemala