| 2. Round | 07/08/2021 | Cobán Imperial | - | Sololá FC | 0:0 | ||||
| 4. Round | 14/08/2021 | Cobán Imperial | - | Achuapa | 2:0 |  |
|||
| 3. Round | 18/08/2021 | Nueva Concepción | - | Cobán Imperial | 2:1 | ||||
| 6. Round | 25/08/2021 | Deportivo Malacateco | - | Cobán Imperial | 1:0 | ||||
| 7. Round | 29/08/2021 | Cobán Imperial | - | Antigua GFC | 0:2 | ||||
| 9. Round | 11/09/2021 | Cobán Imperial | - | Santa Lucía | 0:1 | ||||
| 10. Round | 18/09/2021 | CSD Municipal | - | Cobán Imperial | 2:1 | ||||
| 11. Round | 25/09/2021 | Cobán Imperial | - | Iztapa | 2:1 | |
|||
| 8. Round | 13/10/2021 | Deportivo Guastatoya | - | Cobán Imperial | 0:1 | ||||
| 14. Round | 17/10/2021 | Cobán Imperial | - | Nueva Concepción | 2:0 | ||||
| 15. Round | 23/10/2021 | Achuapa | - | Cobán Imperial | 1:0 | ||||
| 16. Round | 27/10/2021 | Cobán Imperial | - | Comunicaciones | 1:2 | |
|||
| 17. Round | 31/10/2021 | Cobán Imperial | - | Deportivo Malacateco | 1:1 | ||||
| 18. Round | 07/11/2021 | Antigua GFC | - | Cobán Imperial | 2:1 | ||||
| 19. Round | 13/11/2021 | Cobán Imperial | - | Deportivo Guastatoya | 0:1 | |
|||
| 21. Round | 28/11/2021 | Cobán Imperial | - | CSD Municipal | 0:1 | ||||
| 22. Round | 05/12/2021 | Iztapa | - | Cobán Imperial | 5:3 |
Guatemala