| 2. Round | 15/04/2018 | San Antonio FC | - | Orange County SC | 0:3 |  |
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| 2. Round | 23/04/2018 | Fresno FC | - | San Antonio FC | 0:0 | ||||
| 2. Round | 28/04/2018 | Las Vegas Lights FC | - | San Antonio FC | 1:3 | ||||
| 3. Round | 06/05/2018 | San Antonio FC | - | Fresno FC | 2:1 | ||||
| 3. Round | 20/05/2018 | San Antonio FC | - | Tulsa Roughnecks | 1:1 | ||||
| 3. Round | 27/05/2018 | Reno 1868 FC | - | San Antonio FC | 2:1 | |
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| 4. Round | 03/06/2018 | San Antonio FC | - | Portland Timbers 2 | 2:1 | |
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| 4. Round | 17/06/2018 | San Antonio FC | - | Sacramento Republic | 1:0 |  |
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| 4. Round | 24/06/2018 | San Antonio FC | - | Reno 1868 FC | 0:2 | ||||
| 4. Round | 01/07/2018 | Colorado Springs Switchbacks | - | San Antonio FC | 1:1 | ||||
| 5. Round | 05/07/2018 | San Antonio FC | - | OKC Energy FC | 1:1 | ||||
| 5. Round | 15/07/2018 | Orange County SC | - | San Antonio FC | 3:0 | |
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| 5. Round | 26/07/2018 | San Antonio FC | - | Colorado Springs Switchbacks | 1:0 | ||||
| 7. Round | 16/09/2018 | Tulsa Roughnecks | - | San Antonio FC | 2:1 | |
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| 7. Round | 23/09/2018 | Saint Louis FC | - | San Antonio FC | 2:0 | |
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| 8. Round | 07/10/2018 | San Antonio FC | - | Las Vegas Lights FC | 3:1 | ||||
| 8. Round | 14/10/2018 | San Antonio FC | - | Rio Grande Valley FC | 1:1 |
Costa Rica