| 1. Round | 17/01/2010 | CF América | - | Club San Luis | 5:1 | ||||
| 2. Round | 24/01/2010 | Atlante | - | Club San Luis | 2:3 |  |
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| 3. Round | 31/01/2010 | Club San Luis | - | Monarcas Morelia | 0:2 | ||||
| 4. Round | 07/02/2010 | CF Pachuca | - | Club San Luis | 2:0 | ||||
| 5. Round | 14/02/2010 | Club San Luis | - | Indios Juárez | 1:1 |  |
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| 7. Round | 21/02/2010 | Club San Luis | - | Atlas Guadalajara | 3:1 | |
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| 8. Round | 28/02/2010 | Deportivo Guadalajara | - | Club San Luis | 2:0 | ||||
| 9. Round | 07/03/2010 | Club San Luis | - | Cruz Azul | 1:2 | ||||
| 10. Round | 13/03/2010 | Jaguares Chiapas | - | Club San Luis | 1:1 | ||||
| 11. Round | 21/03/2010 | Club San Luis | - | Deportivo Toluca | 2:3 | ||||
| 12. Round | 28/03/2010 | Pumas UNAM | - | Club San Luis | 0:0 | ||||
| 13. Round | 04/04/2010 | Club San Luis | - | UANL Tigres | 0:3 | ||||
| 14. Round | 10/04/2010 | CF Monterrey | - | Club San Luis | 1:1 | ||||
| 15. Round | 15/04/2010 | Club San Luis | - | Estudiantes Tecos | 1:1 |  |
Venezuela