| 3. Round | 15/08/2021 | Platense | - | Real España | 0:2 |  |
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| 4. Round | 22/08/2021 | Lobos UPNFM | - | Platense | 3:0 | |
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| 5. Round | 27/08/2021 | Platense | - | Marathón | 3:1 | ||||
| 6. Round | 29/08/2021 | Real Sociedad | - | Platense | 1:1 | ||||
| 7. Round | 02/09/2021 | Olimpia | - | Platense | 3:0 | ||||
| 12. Round | 03/10/2021 | Honduras Progreso | - | Platense | 4:2 | |
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| 13. Round | 10/10/2021 | Platense | - | Motagua | 2:3 | ||||
| 14. Round | 17/10/2021 | Real España | - | Platense | 2:1 | ||||
| 15. Round | 24/10/2021 | Marathón | - | Platense | 1:1 | ||||
| 16. Round | 28/10/2021 | Platense | - | Victoria | 1:2 | ||||
| 17. Round | 31/10/2021 | Vida | - | Platense | 3:1 | ||||
| 18. Round | 10/11/2021 | Platense | - | Olimpia | 1:4 | |
Honduras